ZO Skin Health - Aggressive Anti-Aging Program
Intensive retinol care with Wrinkle+Texture Repair and Radical Night Repair
About This Treatment
ZO's most intensive anti-aging program centered on high-concentration retinol.
■ Wrinkle + Texture Repair (0.5% retinol): microemulsion delivery, 98% showed wrinkle improvement at 12 weeks. ■ Radical Night Repair (1% retinol): highest concentration with oleosome slow-release technology to minimize irritation while maximizing efficacy.
Physician-guided stepwise retinol concentration increase.
Mechanism of Action
High-concentration retinol (0.5-1%) converts to retinoic acid binding RAR/RXR nuclear receptors: ① upregulates collagen I/III gene expression, ② suppresses MMP-1/MMP-3 to prevent collagen degradation, ③ normalizes epidermal turnover (28-day cycle), ④ inhibits melanosome transfer. Oleosome technology encapsulates retinol in lipid bilayer for gradual release.
Indications
Expected Results
12-week independent study (43 subjects, ages 42-67): 98% showed improvement in crow's feet and facial wrinkles, 100% showed significant texture/smoothness improvement by week 8. Clinically improved skin hydration retention.
Clinical Evidence
Risks & Side Effects
High-frequency retinoid reaction: intense dryness, redness, peeling, stinging for 2-6 weeks. 1% retinol requires physician supervision. Strict sun protection. Contraindicated during pregnancy/nursing.
Interested in this treatment?
Start with an AI skin analysis to check your current skin condition