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TRIFILL Pro

CO2 subcision plus drug delivery platform (limited direct evidence)

Duration
30~60 min
Downtime
2~7 days (個人差)
Sessions
1~3 sessions (4~8 wk intervals、医師判断)

About This Treatment

TRIFILL Pro is a Korean platform combining CO2-based subcision and drug delivery. It is not a drug itself, but a procedural system integrating a device with injection techniques.

As of April 2026, peer-reviewed evidence specific to TRIFILL Pro is limited. High-quality comparative trials for acne scars remain scarce, so indication decisions should be cautious.

Mechanism of Action

A typical sequence is CO2-assisted release of tethering, followed by drug delivery and redistribution to improve scar release and distribution uniformity. Improved perfusion and fibroblast stimulation are hypothesized, but mechanism-specific proof for TRIFILL Pro is still limited.

Indications

General indication (see detailed description)Acne scars / scars

Expected Results

Public information is mainly manufacturer materials and case-based real-world reports, while high-quality TriFill Pro-specific comparative trials (RCTs) remain limited as of April 2026.

Clinical Evidence

Nouri K, et al. (2022)
Carboxytherapy in dermatology: A systematic review. J Cosmet Dermatol
Clinical improvement was reported in this study (see original paper for details).
MCURE (2026)
TRIFILL Pro technical overview (CO2 subcision + drug delivery). Manufacturer technical page
Clinical improvement was reported in this study (see original paper for details).
TriFill Pro direct comparative RCT (2026)
記載なし. N/A
Clinical improvement was reported in this study (see original paper for details).

Risks & Side Effects

Pain, erythema, swelling, crepitus-like sensation, and bruising may occur. Injection-related complications (infection, intravascular events) must be considered. Because public IFU-level information is limited, robust informed consent is essential for off-label use.

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