Prescription Dermatology

Thiamidol / Isobutylamido Thiazolyl Resorcinol

Tyrosinase-inhibiting brightening topical for hyperpigmentation

Duration

topicaldaily

Downtime

なし

Sessions

8-12 weeksで効果判定

About This Treatment

Thiamidol is a human tyrosinase-targeting brightening active used for melasma, solar lentigines, PIH and post-laser pigmentation prevention support.

It is generally easier to integrate into daily care than stronger depigmenting prescriptions, but severe melasma often requires combination therapy.

It inhibits human tyrosinase activity and reduces melanogenesis; photoprotection reduces new pigment stimulation.

Pigmentation / dullnessGeneral indication (see detailed description)

Pigment scores and photography are assessed after 8-12 weeks. It is useful as post-procedure maintenance care.

Arrowitz C, et al. (2019)

Effective tyrosinase inhibition by thiamidol in human pigmentation models. J Invest Dermatol

Clinical improvement was reported in this study (see original paper for details).

Melasma skin-of-color investigators (2025)

Thiamidol in melasma in patients of skin of color. Dermatol Ther

Clinical improvement was reported in this study (see original paper for details).

Mild irritation, redness, dryness and contact dermatitis may occur. Follow product labeling and medical advice in pregnancy/lactation.

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