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Regenerative

Skin Growth Injection

PDLLA microspheres for long-term fibroblast stimulation

Duration
30-45 min
Downtime
1-2 days
Sessions
2-4 sessions (4 wk intervalsで累積効果)

About This Treatment

Skin growth injection (Juvederm Voluma, Sculptra) uses PDLLA (poly-lactic acid) microspheres. Limited direct volume augmentation; instead, gradual PDLLA absorption signals fibroblasts to rebuild. Over 6-12 months, endogenous collagen production accelerates, skin becomes thicker and firmer. Ultimate "growth-promoting" anti-aging treatment.

Mechanism of Action

PDLLA microspheres (40-63μm) trigger granulation tissue formation; macrophages gradually absorb microspheres over 12-24 months. During absorption, fibroblasts chronically stimulated for sustained type I collagen production. Marked improvement at 6 months, peak at 12 months. Endogenous collagen persists after absorption; effects long-lasting.

Indications

General indication (see detailed description)Nasolabial / marionette linesBody contouring / slimming

Expected Results

30% facial volume restoration at 6 months. Marked nasolabial fold and marionette line improvement by 12 months. Effects last 2-3 years. More natural than traditional volumizers; simultaneous skin quality improvement.

Clinical Evidence

Goldberg DJ, Hussain M (2013)
The use of PDLLA injectable for facial rejuvenation. J Cosmet Dermatol
Clinical improvement was reported in this study (see original paper for details).
Mest DR, Humble G (2006)
Injectable poly-L-lactic acid: clinical biochemistry, mechanism of action and theory. Plast Reconstr Surg
Clinical improvement was reported in this study (see original paper for details).

Risks & Side Effects

Transient injection-site redness/swelling (1-2 days), minor bruising. Rare granuloma formation (typically resolves 2-3 weeks). Foreign body sensation rare (PDLLA bioabsorbable).

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