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Cosmetic

RHA Collection (Teoxane)

Resilient HA filler designed for dynamic facial wrinkles

Duration
20-40 min
Downtime
1-2 days
Sessions
1-2 sessions (12-18 monthsevery にmaintenance)

About This Treatment

The RHA Collection by Teoxane is the world's first FDA-approved HA filler specifically designed for dynamic wrinkles. Using proprietary "Preserved Network Technology," it maintains a structure closely mimicking natural hyaluronic acid. Unlike conventional HA products, RHA fillers stretch and move with facial expressions while maintaining structural support.

In 2025, the anesthetic was switched from lidocaine to mepivacaine—the first major anesthetic innovation in HA fillers in nearly two decades. The collection includes RHA 2 (moderate wrinkles), RHA 3 (deep wrinkles), RHA 4 (volume), and RHA Redensity (delicate areas).

Mechanism of Action

Preserved Network Technology minimizes chemical cross-linking while maintaining natural HA molecular structure. This achieves optimal balance between elasticity (G') and viscosity (G"), allowing the filler to move naturally with facial muscles while maintaining structural support.

Indications

Nasolabial / marionette linesWrinkles / fine linesGeneral indication (see detailed description)Lip / mouth contour

Expected Results

Immediate results lasting 15-18 months. Final results stabilize 2-4 weeks post-treatment. 70-85% improvement in dynamic wrinkles. Mepivacaine formulation significantly improves injection comfort compared to lidocaine.

Clinical Evidence

Michaud T, Gassia V, Belhaouari L (2015)
Facial dynamics and emotional expressions change with aging and can be modified by filler injections. J Cosmet Dermatol
Clinical improvement was reported in this study (see original paper for details).
Teoxane Research (Mondon K et al.) (2020)
Resilient Hyaluronic Acid: A new technology for dynamic wrinkle treatment. Dermatol Surg
Clinical improvement was reported in this study (see original paper for details).
FDA Approval Documentation (2024)
RHA Collection: First FDA-approved HA filler for dynamic wrinkles. FDA
Clinical improvement was reported in this study (see original paper for details).

Risks & Side Effects

Injection site redness, swelling, tenderness (resolves in 1-3 days). Rare bruising or nodule formation. Very rare vascular occlusion (reversible with hyaluronidase). Check for mepivacaine allergy history.

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