Relfydess (Ready-to-Use Liquid Toxin)
World's first ready-to-use liquid botulinum toxin lasting 6 months
About This Treatment
Relfydess (RelabotulinumtoxinA) by Galderma is the world's first ready-to-use liquid botulinum toxin A. PEARL Technology™ (Precipitation, Extraction, Activity-preserving Refined Liquid) stabilizes the toxin in liquid form without reconstitution.
Phase 3 READY-1/READY-2 trials achieved >98% responder rate for glabellar lines, with 24-27 week duration (~1.5x longer than traditional Botox). Approved in 20+ countries; FDA BLA accepted in 2026.
Mechanism of Action
PEARL Technology™ maintains botulinum toxin A molecular structure and bioactivity in liquid state. Cleaves SNAP-25 at neuromuscular junction for sustained 6-month acetylcholine suppression. Extended duration attributed to molecular stability in liquid form and uniform diffusion pattern.
Indications
Expected Results
Rapid onset at 48-72 hours. >98% responder rate for glabellar lines. Duration 24-27 weeks (~6 months), requiring only 2 treatments per year. Very high patient satisfaction.
Clinical Evidence
Risks & Side Effects
Headache (most common), transient injection site reactions. Ptosis risk comparable to conventional toxins. Requires refrigeration (2-8°C). Not yet approved in Japan.
Interested in this treatment?
Start with an AI skin analysis to check your current skin condition