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Regenerative

Pluryal Silk / Densify

European PN booster range for delicate and regular skin areas

Duration
15-30 min
Downtime
1-5 days
Sessions
3-4 sessions (2-4 wk intervals)

About This Treatment

Pluryal is a polynucleotide-based Densifier range. Silk is designed for delicate areas such as the periocular and perioral skin; Densify is used for broader facial and neck skin quality.

It is not primarily a volumizing filler but a regenerative booster for hydration, elasticity, fine lines and thin-skin texture.

Mechanism of Action

Long-chain PN creates a hydrated gel microenvironment and may support fibroblast activity, wound repair and inflammation modulation. HA and mannitol in Densify add hydration and antioxidant support.

Indications

Wrinkles / fine linesEye area concernsGeneral indication (see detailed description)Pores

Expected Results

Periorbital protocols commonly assess fine lines, dryness, thin-skin quality and patient satisfaction after 3-4 sessions. Densify is assessed for broader firmness, density and hydration.

Clinical Evidence

Pluryal / MD Skin Solutions (2026)
Pluryal Silk and Densify professional product documentation. Manufacturer documentation
Clinical improvement was reported in this study (see original paper for details).
Aesthetic Surg J Open Forum investigators (2026)
Prospective observational study of polynucleotide injections for periorbital rhytides. Aesthet Surg J Open Forum
Clinical improvement was reported in this study (see original paper for details).
Cavallini M, et al. (2016)
Long-chain polynucleotide filler for skin rejuvenation. Dermatol Ther
Clinical improvement was reported in this study (see original paper for details).

Risks & Side Effects

Wheals, swelling, bruising and tenderness may occur. Periorbital use requires careful product selection and depth control to avoid edema or irregularity.

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