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Regenerative

PDRN/PN Post-Laser Repair

Repair protocol after laser/RF procedures using PN/PDRN

Duration
varies
Downtime
1-7 days
Sessions
元施術に合わせて実施

About This Treatment

This protocol combines PN/PDRN, HA, peptide or soothing topicals after fractional laser, pico-fractional or RF microneedling micro-injury to support recovery.

Korean laser-stacking protocols are popular, but heat and inflammation must be tailored to melasma tendency, skin type and barrier status.

Mechanism of Action

PN/PDRN may support A2A-linked anti-inflammatory, angiogenic and wound-repair pathways, while HA hydrates and barrier topicals reduce TEWL.

Indications

Redness / vascular concernsRF後修復Pigmentation / dullnessGeneral indication (see detailed description)Acne

Expected Results

The goal is to reduce redness, dryness, stinging and PIH risk over days to two weeks after energy-based procedures. Cosmetic improvement depends on the primary procedure.

Clinical Evidence

Korean Medicine scoping review authors (2025)
Laser therapy and PDRN/PN in dermatologic diseases and aesthetic medicine. J Korean Med Ophthalmol Otolaryngol Dermatol
Clinical improvement was reported in this study (see original paper for details).
Feng X, Su H, Xie J (2024)
Microneedling with topical tranexamic acid for melasma. J Cosmet Dermatol
Clinical improvement was reported in this study (see original paper for details).
PDRN review authors (2024)
Polydeoxyribonucleotide in dermatology and aesthetic medicine. Systematic review
Clinical improvement was reported in this study (see original paper for details).

Risks & Side Effects

Risks include erythema, edema, PIH and infection from the primary procedure plus allergy or irritation from adjunct products. Melasma-prone skin requires conservative heat settings.

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