Nucleofill
Italian polynucleotide biorevitalizer for deep tissue repair
About This Treatment
Nucleofill (Italy, Hautpharm) is a biorevitalizing product containing high molecular weight polynucleotides (PN) including DNA/RNA fragments. These directly act on deep dermal tissue, promoting cellular-level repair and structural rejuvenation. Excels at fundamental skin reconstruction and anti-aging benefits.
Mechanism of Action
Polynucleotides activate G-protein coupled receptors (GPCR) on dermal fibroblasts, promoting extracellular matrix (ECM) synthesis. Increases collagen, elastin, and glycosaminoglycan production, dramatically improving skin elasticity and hydration through intracellular repair mechanisms.
Indications
Expected Results
Skin hydration improves within 2-3 weeks with elasticity noticeably enhanced by 4-6 weeks. Results persist for 18-24 months. Deep cellular regeneration provides comprehensive improvements.
Clinical Evidence
Risks & Side Effects
Temporary swelling and erythema for several days post-injection. Rare allergic or hypersensitivity reactions reported. Serious adverse effects are extremely rare.
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