Vitamin B Complex (Neurovitan)
Regulates sebum, protects mucosa, and promotes cell metabolism for foundational skin health
About This Treatment
Vitamin B complex preparations (Neurovitan, Pidoxal, Flavitan etc.) contain B1/B2/B6/B12/niacin. Insurance-covered in Japan. Regulate sebum (B2/B6), maintain mucosal/skin health (B2/B3), promote cellular energy metabolism (B1/B2). Prescribed for stomatitis, angular cheilitis, acne, and seborrheic dermatitis. Niacinamide (B3) notably promotes ceramide synthesis and inhibits melanin transfer.
Mechanism of Action
B2: normalizes sebum as FAD/FMN coenzyme in lipid metabolism. B6: supports skin protein synthesis as amino acid metabolism coenzyme. B3 (niacinamide): promotes ceramide/fatty acid synthesis for barrier function, inhibits melanosome transfer for whitening, anti-inflammatory. B12: supports cell division and DNA synthesis.
Indications
Expected Results
B2/B6: sebum regulation noticeable at 2-4 weeks. Stomatitis improvement in 1-2 weeks. Topical niacinamide (4%): RCT shows significant spot reduction and barrier improvement at 12 weeks. However, oral B complex effects on acne are debated (excess B2/B6 may worsen acne in some cases).
Clinical Evidence
Risks & Side Effects
Generally safe at standard doses. B6 neuropathy risk with high-dose chronic use (>200mg/day). B3 (niacin) flushing possible (not with niacinamide). B2 causes harmless yellow urine. Rare GI symptoms.
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