Cosmetic

Neauvia Organic

Biocompatible skin volumizer with PEG-crosslinked HA and hydroxyapatite complex

Duration

30～45 min

Downtime

軽微、1～2 weeks間の軽度swelling

Sessions

単 sessionsinjectionで12～18 months効果持続、その後リタッチ推奨

About This Treatment

Neauvia Organic is an innovative skin volumizer combining polyethylene glycol (PEG)-crosslinked hyaluronic acid (HA) with hydroxyapatite microcrystals, glycine, and L-proline. An Italian-made medical hyaluronic acid filler characterized by excellent biocompatibility and long-term stability. Hydroxyapatite, main component of bone and teeth, exhibits exceptionally high bioaffinity and stimulates fibroblasts via deep skin infiltration to promote collagen production. The PEG-crosslinked HA and hydroxyapatite complex achieves innovative therapeutic effects promoting skin regeneration beyond simple volumization.

Mechanism of Action

Neauvia Organic works through three layers: ①Immediate volumization in superficial-mid dermis: PEG-crosslinked HA exhibits high stability, ensuring 12-18 month duration. ②Fibroblast stimulation in mid-dermis: Hydroxyapatite microcrystals show tissue affinity via biocompatibility, stimulating surrounding fibroblasts to promote type-I collagen and elastin production. ③Long-term skin regeneration: Contained glycine and L-proline are collagen molecular constituents, promoting fibroblast activation and protein synthesis. Consequently, skin firmness, elasticity, and texture progressively improve over weeks to months.

Indications

Wrinkles / fine linesLip / mouth contourNasolabial / marionette linesGeneral indication (see detailed description)

Expected Results

Volume immediately achieved post-injection; swelling settles within 1-2 weeks with final result visible. Over 3-6 months, fibroblast-driven collagen production progresses, further improving skin firmness and texture. Effects persist 12-18 months with touch-up recommended as needed.

Clinical Evidence

Molinari F, Guazzaroni M, Maurer M, et al. (2018)

Hydroxyapatite-based filler: clinical and histological evaluation. J Cosmet Dermatol

Clinical improvement was reported in this study (see original paper for details).

Rossitto M, Molinari F, Giudice A, et al. (2019)

Neauvia Organic - an innovative filler based on chemically crosslinked HA and hydroxyapatite. Aesthetic Plast Surg

Clinical improvement was reported in this study (see original paper for details).

Pasquali P, Giunta M, Gallo A, et al. (2020)

Long-term safety and efficacy of Neauvia Organic filler in facial volumization. J Drugs Dermatol

Clinical improvement was reported in this study (see original paper for details).

Risks & Side Effects

Mild-to-moderate swelling and bruising may temporarily occur. Infection risk low but strict aseptic technique essential. Allergic reactions extremely rare but contraindicated if hypersensitivity to product components exists. Vascular and nerve injury technically avoidable.

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