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Regenerative

NCTF 135HA (FILLMED)

HA + growth factors + amino acids for bio-revitalization

Duration
20-30 min
Downtime
1-2 days
Sessions
3-4 sessions (1-2 wk intervals)

About This Treatment

NCTF 135HA (New Cellular Treatment Factor) by FILLMED contains non-crosslinked HA combined with 53 active ingredients (12 vitamins, 23 amino acids, 6 coenzymes, 6 minerals, 5 nucleic acid bases, 1 antioxidant).

Activates fibroblasts and promotes collagen synthesis for comprehensive improvement in skin hydration, elasticity, and radiance through mesotherapy injection.

Mechanism of Action

53 active ingredients directly supply nutrients to fibroblasts. Non-crosslinked HA provides immediate hydration, while amino acids, vitamins, and nucleic acids promote DNA repair and protein synthesis. Coenzymes optimize mitochondrial function and cellular energy metabolism.

Indications

Wrinkles / fine linesGeneral indication (see detailed description)Pigmentation / dullnessElasticity / firmness

Expected Results

Randomized prospective controlled multicenter study (146 subjects) confirmed significant wrinkle reduction at day 75 and 120 in crow's feet, neck, and décolleté. Skin hydration significantly increased 7 days post-injection. Maximum effect after 3-4 treatment series.

Clinical Evidence

Sparavigna A, Tenconi B, De Ponti I (2023)
Randomized prospective controlled multicenter study of NCTF 135HA bio-revitalization. Clin Exp Dermatol
Clinical improvement was reported in this study (see original paper for details).
Vedamurthy M, Perper M (2025)
Split-face trial of NCTF 135HA combined with botulinum toxin. J Cosmet Dermatol
Clinical improvement was reported in this study (see original paper for details).

Risks & Side Effects

Mild injection pain (reducible with anesthetic cream). Injection site redness and papules (resolve within 24-48 hours). Rare bruising. Allergic reactions (extremely rare). Infection risk (prevented with proper sterilization).

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