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Regenerative

LIZNE PN Skin Booster

High-purity PN salmon-DNA booster for repair and texture

Duration
15-30 min
Downtime
1-5 days
Sessions
3-4 sessions (2-3 wk intervals)

About This Treatment

LIZNE is a Korean PN skin booster in the same family as Rejuran-like salmon-DNA products, marketed as high-purity PN with less injection pain and redness.

It is used for redness, thin or dry skin, pores, fine lines and post-acne texture as a repair-oriented booster, not as a volumizing filler.

Mechanism of Action

PN supports dermal hydration and may modulate A2A-related repair, inflammation and fibroblast/ECM pathways.

Indications

General indication (see detailed description)Redness / vascular concernsWrinkles / fine linesPoresAcne

Expected Results

Typically assessed after 3-4 sessions every 2-3 weeks for firmness, redness, dryness and texture. PN results are gradual repair rather than immediate shape change.

Clinical Evidence

LIZNE product documentation (2026)
LIZNE polynucleotide sodium product list. Manufacturer documentation
Clinical improvement was reported in this study (see original paper for details).
Kim JH, et al. (2022)
Effects of polynucleotide dermal filler in the correction of crow feet. J Cosmet Dermatol
Clinical improvement was reported in this study (see original paper for details).
Cavallini M, et al. (2016)
Long-chain polynucleotide filler for skin rejuvenation. Dermatol Ther
Clinical improvement was reported in this study (see original paper for details).

Risks & Side Effects

Injection pain, wheals, erythema, swelling and bruising may occur. Fish-derived ingredient allergy should be checked.

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