Cosmetic

Lenisna (PDLLA + HA Hybrid)

PDLLA + HA hybrid biostimulator for liquid thread lift effect

Duration

20-30 min

Downtime

1-3 days

Sessions

2 sessions (4-6 wk intervals)

About This Treatment

Lenisna is a hybrid biostimulator from Regen Biotech (Korea) containing 170mg PDLLA (poly-D,L-lactic acid) + 30mg non-crosslinked hyaluronic acid. With approximately 4x more PDLLA than standard Juvelook (42.5mg), it achieves a gentle "liquid thread lift" effect.

PDLLA microspheres (50-60μm) act as dermal scaffolding to activate fibroblasts and promote type I & III neocollagenesis. HA provides immediate hydration and helps distribute PDLLA evenly, delivering natural results from the moment of injection.

Mechanism of Action

PDLLA microspheres (50-60μm) activate surrounding fibroblasts via TGF-β1 pathway, promoting type I collagen production. PDLLA hydrolyzes over 12-24 months into lactic acid. Non-crosslinked HA is absorbed within 48-72 hours, providing initial hydration and injection uniformity.

Indications

Nasolabial / marionette linesSagging / contourElasticity / firmnessGeneral indication (see detailed description)Eye area concerns

Expected Results

Immediate hydration effect from HA. Collagen-driven lifting peaks at 1-3 months. Duration 12-24 months. 4x PDLLA content provides more pronounced lifting than standard Juvelook.

Clinical Evidence

Kim JH, Park JY, et al. (2024)

Efficacy and Safety of Poly-D,L-Lactic Acid and Hyaluronic Acid Hybrid Filler for Facial Rejuvenation. J Cosmet Dermatol

Clinical improvement was reported in this study (see original paper for details).

Regen Biotech Clinical Data (2025)

Comparative Analysis of High-Concentration PDLLA Biostimulator vs. Standard Formulation. Aesthet Surg J

Clinical improvement was reported in this study (see original paper for details).

Lee SY, Kim HJ (2023)

PDLLA microspheres as dermal scaffolding for neocollagenesis. J Dermatol Sci

Clinical improvement was reported in this study (see original paper for details).

Risks & Side Effects

Injection site swelling/redness (2-5 days). Rare nodule formation (especially with overcorrection in thin skin). PDLLA is non-reversible. Technique-dependent results require experienced injectors.

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