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Cosmetic

Dysport

AbobotulinumtoxinA | Wider spread, faster onset

Duration
10-20 min
Downtime
0 days
Sessions
3-4 monthsevery

About This Treatment

Dysport (Ipsen/Galderma, France) is AbobotulinumtoxinA with smaller protein complex than Botox, resulting in wider diffusion from injection site. Effective for broader wrinkle areas. Faster onset—many patients see results within 3 days.

Long European history, EMA-approved. Ideal for large wrinkle areas or multiple simultaneous sites.

Mechanism of Action

AbobotulinumtoxinA has same SNAP-25 cleavage mechanism as OnabotulinumtoxinA but different protein complex. Ona is 150kDa complex while Abo is non-complexed or smaller complex. Results in wider diffusion post-injection and broader effect on adjacent muscles. Faster onset possibly due to smaller molecular size.

Indications

Wrinkles / fine linesGeneral indication (see detailed description)

Expected Results

Fast onset—many patients see results within 3-5 days. Peak effect at 2-4 weeks. Duration 3-4 months similar to Botox. Wider diffusion makes it ideal for broader wrinkle areas.

Clinical Evidence

Lowe NJ, Ascher B, Harlaar B, et al. (2002)
Double-Blind, Randomized, Placebo-Controlled Clinical Trial of the Safety and Efficacy of Botulinum Toxin Type A in Subjects with Glabellar Lines. Plast Reconstr Surg
Clinical improvement was reported in this study (see original paper for details).
Braccini F, Christelle B, Alain A, et al. (2015)
Consensus on the Use of Botulinum Toxins in the Management of Facial Lines. J Cosmet Dermatol
Clinical improvement was reported in this study (see original paper for details).

Risks & Side Effects

Injection pain/swelling/bruising. Wider diffusion carries slightly higher risk of unintended muscle weakness (eye/lip droop). Important to avoid overdosing. Possible antibody formation.

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