Botox Cosmetic
OnabotulinumtoxinA | Global standard for preventing and treating dynamic wrinkles
About This Treatment
Botox Cosmetic (Allergan/AbbVie, USA) is OnabotulinumtoxinA that inhibits acetylcholine release at neuromuscular junction, reducing excessive muscle contraction. First cosmetic botulinum toxin FDA approval, used in 50+ countries.
Botox Cosmetic has strong muscle-weakening effect, providing both preventive wrinkle reduction and treatment of existing wrinkles. Flexible dose adjustment for physician skill and patient goals.
Mechanism of Action
Botulinum toxin A cleaves SNAP-25 protein of SNARE complex (between amino acids 140-141), blocking synaptic vesicle fusion and acetylcholine release. Neuromuscular transmission is blocked. Onset 3-5 days post-injection, peak effect 2-4 weeks. Wanes after ~3-4 months as new nerve terminals regenerate.
Indications
Expected Results
Onset 3-5 days, peak 2-4 weeks. Duration 3-6 months. Regular repeat treatments (every 3-4 months) suppress muscle overactivity, enhancing wrinkle prevention. Long-term benefits accumulate after 2-3 repeat sessions.
Clinical Evidence
Risks & Side Effects
Injection pain/swelling/bruising, rare brow ptosis, dry eye sensation, transient headache. Anatomical knowledge essential to prevent asymmetry. Possible antibody formation reducing efficacy (1-3% with frequent use). Overdosing causes frozen appearance.
Interested in this treatment?
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