Anti-Aging

Botox

Prevention and treatment of dynamic wrinkles

Duration

10-20 min

Downtime

0 days

Sessions

3-6 monthsevery

About This Treatment

Botox (Botulinum toxin type A) inhibits acetylcholine release at the neuromuscular junction, reducing excessive muscle contraction. FDA-approved for forehead lines, glabellar lines, and crow's feet.

Preventive Botox can also prevent wrinkle formation.

Mechanism of Action

Botulinum toxin A cleaves SNAP-25 protein of the SNARE complex, preventing acetylcholine vesicle fusion with cell membrane. Neuromuscular transmission is blocked. Effect onset 3-5 days, peak at 2-4 weeks, wanes at 3-4 months as nerve terminals regenerate.

Indications

Wrinkles / fine linesSagging / contourHyperhidrosisGeneral indication (see detailed description)

Expected Results

Onset in 3-5 days, peak at 2-4 weeks. Duration 3-6 months. Regular repeat treatments enhance wrinkle prevention.

Clinical Evidence

Carruthers JD, Carruthers JA (1992)

Treatment of glabellar frown lines with C. botulinum-A exotoxin. J Dermatol Surg Oncol

Clinical improvement was reported in this study (see original paper for details).

Sundaram H, Signorini M, Liew S, et al. (2016)

Global aesthetics consensus: botulinum toxin type A—evidence-based review. Plast Reconstr Surg

Clinical improvement was reported in this study (see original paper for details).

Risks & Side Effects

Injection site pain/bruising, rare brow ptosis, asymmetry. Proper injection technique and anatomical knowledge essential. Possible antibody formation reducing efficacy.

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