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Regenerative

BNAJU / Re2O ECM Booster

Korean next-generation hADM-derived ECM skin booster

Duration
20-40 min
Downtime
1-5 days
Sessions
3-4 sessions (3-4 wk intervals)

About This Treatment

BNAJU, marketed as Re2O in Korea, is a particulate human acellular dermal matrix (hADM) ECM skin booster. Instead of only inducing repair signals like PN/PDRN, it aims to supplement dermal extracellular-matrix components such as collagen, elastin and glycosaminoglycans.

In Korea it is positioned as an ECM booster for pores, fine lines, laxity, dryness and post-laser skin-quality rebuilding. Product provenance, tissue processing controls and local regulatory status should be verified before use.

Mechanism of Action

Decellularized hADM reduces cellular immunogenicity while retaining dermal ECM scaffolding. Intradermal particles may support fibroblast migration, ECM synthesis, basement-membrane recovery and hyaluronan production.

Indications

General indication (see detailed description)PoresWrinkles / fine linesElasticity / firmness

Expected Results

A randomized split-face study reported greater improvements in skin density, elasticity, hydration, pores and TEWL versus HA control. Clinically, 3-4 induction sessions are often assessed over 8-20 weeks.

Clinical Evidence

Lee YI, Chau NH, Nguyen NH, et al. (2026)
Injectable particulated human acellular dermal matrix booster for skin restoration. Int J Mol Sci
Clinical improvement was reported in this study (see original paper for details).
Huang J, Heng S, Zhang W, et al. (2022)
Dermal extracellular matrix molecules in skin development, homeostasis, wound regeneration and diseases. Semin Cell Dev Biol
Clinical improvement was reported in this study (see original paper for details).
BNAJU/Re2O clinic documentation (2026)
Re2O/BNAJU hADM ECM skin booster product descriptions. Product/clinic information
Clinical improvement was reported in this study (see original paper for details).

Risks & Side Effects

Injection pain, erythema, edema, bruising, wheals and nodules may occur. Because it is human-tissue derived, traceability, sterility and regulatory status must be verified.

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