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Regenerative

BM-MSC Therapy

Stem cells from bone marrow | Skin regeneration and anti-aging

Duration
採取30-45 min+injection30 min
Downtime
2-3 days (採取部位)
Sessions
1 sessions (培養期間2-4 weeks間)

About This Treatment

BM-MSC therapy harvests bone marrow from patient's iliac bone (pelvic bone), isolates and cultures stem cells, then injects into skin. BM-MSCs possess strong paracrine signaling, stimulating dermal fibroblasts and promoting collagen production.

Reports indicate BM-MSCs provide UV photoaging protection, offering extracellular matrix preservation and repair. Bone marrow harvesting requires medical expertise, but obtained stem cells are high-quality with strong multipotency.

Mechanism of Action

BM-MSC-secreted growth factors (HGF, IGF-1, VEGF, FGF) act on dermal fibroblasts, increasing collagen synthesis. Simultaneously protect mitochondrial function and mitigate UV-induced oxidative stress. BM-MSCs possess immunomodulatory capacity, reducing chronic inflammation to delay skin aging.

Indications

General indication (see detailed description)Wrinkles / fine linesSagging / contour

Expected Results

Post-BM-MSC treatment, skin photoaging scores improve. Collagen fiber density increases, texture enhances. UV-damage-related spots and wrinkles tend to decrease. Results perceived at 3-6 months.

Clinical Evidence

Bone Marrow MSC Research Group (2022)
Enhances skin regeneration through paracrine signaling and UV protection. Stem Cell Res Ther
Clinical improvement was reported in this study (see original paper for details).
Chen et al. (2021)
BM-MSC secretome promotes wound healing in irradiated skin. Regenerative Medicine
Clinical improvement was reported in this study (see original paper for details).

Risks & Side Effects

Pain during bone marrow extraction and temporary discomfort at harvest site. Infection risk minimal. Technique-dependent—experienced physician-performed procedure important.

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