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Regenerative

Ameela / Nucleadyn Polynucleotides

European PN booster for periocular, neck and skin quality

Duration
15-30 min
Downtime
1-5 days
Sessions
3 sessions (2-4 wk intervals)

About This Treatment

Ameela/Nucleadyn is a European polynucleotide injectable used for periocular skin, neck, decollete, thin skin and crepey texture where volumizing filler is not desired.

Brand-specific peer-reviewed data are limited, so counseling should rely on broader PN evidence and anatomy-specific risk control.

Mechanism of Action

PN acts as a hydrating polymer and supports fibroblast, ECM, antioxidant and anti-inflammatory repair pathways without major volumization.

Indications

Wrinkles / fine linesGeneral indication (see detailed description)

Expected Results

Three sessions spaced 2-4 weeks apart are assessed for thin-skin texture, fine lines and dryness. Periocular treatment requires small aliquots and edema monitoring.

Clinical Evidence

Polynucleotide systematic review authors (2025)
The effectiveness of polynucleotides in esthetic medicine. J Cosmet Dermatol
Clinical improvement was reported in this study (see original paper for details).
Kim JH, et al. (2022)
Effects of polynucleotide dermal filler in the correction of crow feet. J Cosmet Dermatol
Clinical improvement was reported in this study (see original paper for details).

Risks & Side Effects

Wheals, edema, bruising and tenderness may occur. Periocular and neck areas require careful volume and depth control.

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