Xeomin
IncobotulinumtoxinA | Pure toxin, protein complex-free
이 치료에 대해
Xeomin (Merz, Germany) is IncobotulinumtoxinA—the only botulinum toxin A without accessory proteins (complexing proteins). Called "naked toxin," it contains only active ingredient, theoretically lowering antibody formation risk.
Smallest molecular size due to lack of complex. Diffusion range between Botox/Dysport. Efficacy equals Botox with potentially lower antibody-related efficacy reduction.
작용 기전
IncobotulinumtoxinA cleaves same SNAP-25 site as other BoNT-A toxins, so mechanism is identical. However, absence of complexing proteins reduces immune system's chance to recognize foreign matter. Theoretically lower neutralizing antibody formation, though clinical significance not yet confirmed.
적응증
기대 효과
Equivalent efficacy to Botox. Onset 3-5 days, peak 2-4 weeks, duration 3-4 months. Advantage: theoretically lower antibody-related efficacy reduction.
임상 근거
위험 및 부작용
Injection pain/swelling/bruising. Brow ptosis and dry eye risk equivalent to Botox. Antibody-related efficacy reduction theoretically lower, though clinical significance unconfirmed.