Vitamin A (Chocola A)
Supplementing essential vitamin A for epithelial differentiation and skin homeostasis restoration
이 치료에 대해
Chocola A contains retinol palmitate (vitamin A), insurance-covered in Japan. Vitamin A is essential for normal epithelial differentiation and maintenance. Used for keratinization disorders, mucosal protection, and immune function. In dermatology prescribed for dry skin, keratinization abnormalities, and night blindness. Oral route provides systemic effects unlike topical retinol.
작용 기전
Retinol metabolized to retinal (vision) and retinoic acid (gene regulation). Retinoic acid binds RAR/RXR to regulate HOX genes maintaining normal keratinocyte differentiation. Vitamin A deficiency causes squamous metaplasia and impaired barrier. Supplementation restores keratinization, barrier function, and collagen metabolism. Note: physiologic supplementation, not pharmacologic retinoid effect like isotretinoin.
적응증
기대 효과
Vitamin A deficiency symptoms (dry skin, keratinization) improve within 2-4 weeks. 26-week topical retinol study showed significant wrinkle improvement (oral supplementation evidence for direct cosmetic effects is more limited). Turnover normalization requires 1-2 months.
임상 근거
위험 및 부작용
MAJOR: Hypervitaminosis A risk with excess (headache, nausea, liver damage, bone density loss). Fat-soluble accumulation risk. Teratogenic in pregnancy (caution >5,000IU/day, clear risk >15,000IU/day). Safe at standard doses (5,000-10,000IU/day) but watch for supplement overlap.