Ellansé (PCL Biostimulator)
PCL microspheres for instant volume + long-term collagen stimulation
이 치료에 대해
Ellansé is a biostimulatory filler containing polycaprolactone (PCL) microspheres (25-30%) suspended in carboxymethyl cellulose (CMC) gel. The CMC gel provides immediate volume, while PCL microspheres act as scaffolding to activate fibroblasts.
As PCL gradually biodegrades, neocollagen is produced, eventually replacing the PCL entirely with natural collagen. Available in S (1yr), M (2yr), L (3yr), and E (4yr) variants.
작용 기전
PCL microspheres (25-50μm diameter) physically stimulate surrounding fibroblasts, activating TGF-β pathway to promote type I and III collagen synthesis. PCL gradually degrades via hydrolysis into CO2 and H2O. CMC gel is absorbed within 2-3 months, by which time neocollagen maintains volume.
적응증
기대 효과
Immediate results (CMC gel volume) + long-term results (neocollagen). Maximum effect at 3-6 months. Duration 1-4 years depending on type. Patient satisfaction 80-90%.
임상 근거
위험 및 부작용
Injection site swelling and tenderness (3-7 days). Rare nodule/granuloma formation (especially in thin-skinned areas). Non-reversible (cannot be dissolved with hyaluronidase). Avoid overcorrection. Very rare biofilm infection risk.