Cinal (Ascorbic Acid + Calcium Pantothenate)
Insurance-covered vitamin C formulation inhibiting melanin at multiple steps while promoting collagen synthesis
이 치료에 대해
Cinal tablets contain ascorbic acid (vitamin C) 200mg and calcium pantothenate (vitamin B5) 3mg. Insurance-covered in Japan. Ascorbic acid provides multi-faceted beauty benefits: tyrosinase inhibition for melanin suppression, reduction of oxidized melanin for depigmentation, collagen synthesis promotion, and ROS scavenging. Pantothenate normalizes skin turnover as a CoA component.
작용 기전
Ascorbic acid: ①chelates copper ions in tyrosinase to inhibit melanin synthesis, ②reduces oxidized melanin (brown) to leucomelanin (light), ③promotes collagen I/III synthesis as hydroxylation cofactor, ④scavenges ROS to prevent photoaging. Pantothenate supports CoA synthesis, lipid metabolism, barrier function, and epithelial regeneration.
적응증
기대 효과
Visible lightening of pigmentation at 3-6 months. Serum vitamin C reaches steady state in 1-2 weeks, but clinical effect requires melanin turnover time. Synergistic when combined with tranexamic acid or L-cysteine.
임상 근거
위험 및 부작용
Generally very safe. Rare GI symptoms (nausea, diarrhea). Theoretical kidney stone risk at very high doses (not with standard dosing). May cause false negatives in urine tests. Caution in hemochromatosis due to enhanced iron absorption.