Botox
Prevention and treatment of dynamic wrinkles
이 치료에 대해
Botox (Botulinum toxin type A) inhibits acetylcholine release at the neuromuscular junction, reducing excessive muscle contraction. FDA-approved for forehead lines, glabellar lines, and crow's feet.
Preventive Botox can also prevent wrinkle formation.
작용 기전
Botulinum toxin A cleaves SNAP-25 protein of the SNARE complex, preventing acetylcholine vesicle fusion with cell membrane. Neuromuscular transmission is blocked. Effect onset 3-5 days, peak at 2-4 weeks, wanes at 3-4 months as nerve terminals regenerate.
적응증
기대 효과
Onset in 3-5 days, peak at 2-4 weeks. Duration 3-6 months. Regular repeat treatments enhance wrinkle prevention.
임상 근거
위험 및 부작용
Injection site pain/bruising, rare brow ptosis, asymmetry. Proper injection technique and anatomical knowledge essential. Possible antibody formation reducing efficacy.