Azelaic Acid
Naturally derived dicarboxylic acid | Brightening, anti-inflammatory, pore care
이 치료에 대해
Azelaic acid is a naturally occurring C9 dicarboxylic acid found in grains (wheat, barley, rye) with multifaceted pharmacological effects in dermatology. It inhibits tyrosinase to suppress melanin production, provides antibacterial activity (particularly against Cutibacterium acnes), anti-inflammatory effects (suppressing reactive oxygen species), and normalizes keratinization.
Prescribed at 15-20% concentration in aesthetic dermatology in Japan; FDA-approved for rosacea treatment in the West. Notable for pregnancy safety (FDA Category B). Useful as alternative therapy for patients intolerant to hydroquinone or retinoids.
작용 기전
Azelaic acid has multiple mechanisms: (1) Competitively inhibits tyrosinase, suppressing melanin synthesis in melanosomes (brightening). (2) Inhibits protein synthesis of aerobic and anaerobic bacteria, exerting direct antibacterial activity against C. acnes and Staphylococcus. (3) Functions as a scavenger of neutrophil-generated reactive oxygen species (ROS), suppressing inflammatory cascades. (4) Normalizes abnormal keratinization, preventing follicular occlusion (comedone formation). These multifaceted actions work synergistically for acne, hyperpigmentation, and rosacea.
적응증
기대 효과
Inflammatory acne reduction observed 4-8 weeks after starting 15-20% azelaic acid. Significant hyperpigmentation improvement with 12 weeks continuous use. Rosacea erythema and papules reduce at 8-12 weeks. Clinical data shows brightening efficacy comparable to 4% hydroquinone with lower irritation potential.
임상 근거
위험 및 부작용
Mild initial irritation (stinging, itching, burning sensation) may occur but typically subsides within 2-4 weeks. Serious adverse effects extremely rare. No ochronosis risk unlike hydroquinone, enabling long-term use. Safe during pregnancy and lactation (FDA Category B).