Ellansé (PCL Biostimulator)
PCL microspheres for instant volume + long-term collagen stimulation
About This Treatment
Ellansé is a biostimulatory filler containing polycaprolactone (PCL) microspheres (25-30%) suspended in carboxymethyl cellulose (CMC) gel. The CMC gel provides immediate volume, while PCL microspheres act as scaffolding to activate fibroblasts.
As PCL gradually biodegrades, neocollagen is produced, eventually replacing the PCL entirely with natural collagen. Available in S (1yr), M (2yr), L (3yr), and E (4yr) variants.
Mechanism of Action
PCL microspheres (25-50μm diameter) physically stimulate surrounding fibroblasts, activating TGF-β pathway to promote type I and III collagen synthesis. PCL gradually degrades via hydrolysis into CO2 and H2O. CMC gel is absorbed within 2-3 months, by which time neocollagen maintains volume.
Indications
Expected Results
Immediate results (CMC gel volume) + long-term results (neocollagen). Maximum effect at 3-6 months. Duration 1-4 years depending on type. Patient satisfaction 80-90%.
Clinical Evidence
Risks & Side Effects
Injection site swelling and tenderness (3-7 days). Rare nodule/granuloma formation (especially in thin-skinned areas). Non-reversible (cannot be dissolved with hyaluronidase). Avoid overcorrection. Very rare biofilm infection risk.
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