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Hydration
Hada Labo

Premium Hyaluronic Acid Serum (Gokujyun Premium)

7 types of hyaluronic acid for deep hydration

Category
Serum
Price
¥800〜¥1,500
Rating
4.4/5
乾燥肌全肌質対応

Key Ingredients

多層ヒアルロン酸(7種)
Seven types of different molecular weight HA. High-MW HA forms surface barrier; low-MW/nano-HA penetrates deep into stratum corneum.
乳酸球菌/ヒアルロン酸発酵液
Fermentation technology produces low-molecular HA with ~2x stratum corneum penetration vs. conventional products.

How It Works

Hyaluronic acid (HA) is a glycosaminoglycan of glucuronic acid/N-acetylglucosamine disaccharide repeats, holding ~1,000x its weight in water. High-MW HA (>1,000kDa) forms a viscoelastic film reducing TEWL. Medium-MW HA (100-1,000kDa) penetrates upper stratum corneum. Low-MW HA (<100kDa) and nano-HA (<10kDa) reach deep stratum corneum, improving keratinocyte hydration. Multi-layer approach provides both immediate moisture sensation and sustained deep hydration.

How to Use

After cleansing and toner, apply 2-3 drops to slightly damp skin with gentle pressing. Avoid applying to dry skin as it may draw moisture out. Always seal with cream or oil afterwards.

Expected Results

Immediate plumping and hydration sensation. Fine lines from dehydration less visible at 1-2 weeks. After 4+ weeks, sustained stratum corneum hydration improvement and strengthened barrier.

Scientific Evidence

Papakonstantinou E, Roth M, Karakiulakis G (2012)
Hyaluronic acid: a key molecule in skin aging. Dermato-EndocrinologyDOI: 10.4161/derm.21923
ヒアルロン酸の皮膚老化における役割を詳述。外用HAが角質層の含水量を有意に増加させ、小ジワを改善することを確認。
Pavicic T, Gauglitz GG, Lersch P, et al. (2011)
Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. J Drugs Dermatol
異なる分子量のHA配合クリームの抗シワ効果を比較。低分子HAほど深部への浸透が優れ、高分子HAは表面保護に優れることを実証。

Precautions

In dry environments (<40% humidity), HA may draw moisture from skin instead of air. Always seal with cream/oil in dry conditions. Store at room temperature away from direct sunlight.

Related Professional Treatments

Professional treatments that pair well with this home care product.

Mesotherapy Hydrafacial

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■ Disclaimer
Information on this page is based on scientific literature and does not guarantee product results. Effects vary by individual. Discontinue use and consult a dermatologist if skin issues occur.